Bisphenol A (BPA) and cell signaling pathways

Biotechnol Adv. 2018 Jan-Feb;36(1):311-327. doi: 10.1016/j.biotechadv.2017.12.002. Epub 2017 Dec 8.

Abstract

Bisphenol A (BPA; 4,4'-isopropylidenediphenol) is an endocrine disruptor that is used as a material for the production of phenol resins, polyacrylates, polyesters, epoxy resins, and polycarbonate plastics. Endocrine-disruptive or toxic effects of BPA on living organisms through a number of cell signaling pathways have been reported. BPA induces carcinogenesis, reproductive toxicity, abnormal inflammatory or immune response, and developmental disorders of brain or nervous system through various cell signaling pathways. This review considers the literature concerning BPA and its association with cancer-related cell signaling pathways, reproductive toxicity-related cell signaling pathways, inflammatory or immune response-related cell signaling pathways, and brain and nervous system-related cell signaling pathways.

Keywords: Bisphenol A; Brain; Cancer; Cell signaling; Immune response; Inflammation; Metabolic disease; Nervous system; Reproductive toxicity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Benzhydryl Compounds* / adverse effects
  • Benzhydryl Compounds* / pharmacology
  • Cell Line
  • Cell Physiological Phenomena / drug effects
  • Cell Physiological Phenomena / physiology
  • Humans
  • Mice
  • Models, Biological
  • Neoplasms / metabolism
  • Phenols* / adverse effects
  • Phenols* / pharmacology
  • Signal Transduction* / drug effects
  • Signal Transduction* / physiology

Substances

  • Benzhydryl Compounds
  • Phenols
  • bisphenol A