Abstract
The tubers of the medicinal plant Hemsleya penxianensis (Cucurbitaceae) yielded 11 cucurbitane-type triterpenes Xuedanencins A-K by silica gel column, ODS column, and pre-HPLC techniques. Their structures were determined by spectroscopic analysis and examined alongside existing data from prior studies. Separated compounds were evaluated for cytotoxic activity against the Hela human cancer cell line and compounds 7 and 8 showed significant cytotoxicity with IC50 values at 1.82 and 2.45 μM, respectively.
Keywords:
Cucurbitane-type triterpenes; Cytotoxic activity; Hemsleya penxianensis (Cucurbitaceae).
Copyright © 2017 Elsevier Ltd. All rights reserved.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Cucurbitaceae / chemistry*
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Glycosides / chemistry
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Glycosides / isolation & purification
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Glycosides / pharmacology*
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HeLa Cells
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Humans
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Molecular Conformation
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Structure-Activity Relationship
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Triterpenes / chemistry
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Triterpenes / isolation & purification
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Triterpenes / pharmacology*
Substances
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Antineoplastic Agents, Phytogenic
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Glycosides
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Triterpenes
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cucurbitane