Flavonoid glycosides and alkaloids from the embryos of Nelumbo nucifera seeds and their antioxidant activity

Xi-Lan Jiang; Lun Wang; En-Jun Wang; Guo-Lin Zhang; Bin Chen; Ming-Kui Wang; Fu Li

doi:10.1016/j.fitote.2018.01.009

Flavonoid glycosides and alkaloids from the embryos of Nelumbo nucifera seeds and their antioxidant activity

Fitoterapia. 2018 Mar:125:184-190. doi: 10.1016/j.fitote.2018.01.009. Epub 2018 Jan 31.

Authors

Xi-Lan Jiang¹, Lun Wang², En-Jun Wang³, Guo-Lin Zhang³, Bin Chen³, Ming-Kui Wang⁴, Fu Li⁵

Affiliations

¹ School of Pharmacy and Bioengineering, Chengdu University, Chengdu 610106, China; Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration, Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China; Key Laboratory of Exploitation and Study of Distinctive Plants in Education Department of Sichuan Province, Sichuan University of Arts and Science, Dazhou 635000, China.
² School of Pharmacy and Bioengineering, Chengdu University, Chengdu 610106, China; Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration, Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China. Electronic address: wanglun@cib.ac.cn.
³ Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration, Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
⁴ School of Pharmacy and Bioengineering, Chengdu University, Chengdu 610106, China; Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration, Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
⁵ School of Pharmacy and Bioengineering, Chengdu University, Chengdu 610106, China; Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration, Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China. Electronic address: lifu@cib.ac.cn.

PMID: 29371159
DOI: 10.1016/j.fitote.2018.01.009

Abstract

Chemical investigation of the embryos of Nelumbo nucifera afforded four new flavone C-glycosides, named nelumbosides A-D (1-4), together with nine known ones, comprising five flavonoids (5-9) and four alkaloids (10-13). The chemical structures of the new compounds were elucidated by 1D, 2D-NMR and HR-ESI-MS techniques, together with chemical methods. Nelumbosides A-D (1-4) are rarely present in naturally occurring flavone C-glycosides featuring a 4-hydroxystyrene unit connected to the flavonoid skeleton. Compounds 2-13 were evaluated for their antioxidant activity by ABTS and DPPH radical-scavenging assay. Among them, compounds 2, 6, 7 and 11 exhibited strong scavenging activity with SC₅₀ values ranging from 12.07 to 25.68μM compared with the positive control l-ascorbic acid.

Keywords: Alkaloids; Antioxidant activity; Flavonoid glycosides; Nelumbo nucifera.

MeSH terms

Alkaloids / chemistry*
Alkaloids / isolation & purification
Antioxidants / chemistry*
Antioxidants / isolation & purification
Flavonoids / chemistry*
Flavonoids / isolation & purification
Glycosides / chemistry*
Glycosides / isolation & purification
Molecular Structure
Nelumbo / chemistry*
Seeds / chemistry

Substances

Alkaloids
Antioxidants
Flavonoids
Glycosides