Colletotrichine B, a new sesquiterpenoid from Colletotrichum gloeosporioides GT-7, a fungal endophyte of Uncaria rhynchophylla

Xiao-Wei Chen; Zhong-Duo Yang; Xiao-Fei Li; Jian-Hui Sun; Li-Jun Yang; Xin-Guo Zhang

doi:10.1080/14786419.2018.1437437

Colletotrichine B, a new sesquiterpenoid from Colletotrichum gloeosporioides GT-7, a fungal endophyte of Uncaria rhynchophylla

Nat Prod Res. 2019 Jan;33(1):108-112. doi: 10.1080/14786419.2018.1437437. Epub 2018 Feb 8.

Authors

Xiao-Wei Chen^{1

2}, Zhong-Duo Yang¹, Xiao-Fei Li¹, Jian-Hui Sun¹, Li-Jun Yang¹, Xin-Guo Zhang¹

Affiliations

¹ a School of Life Science and Engineering , Lanzhou University of Technology , Lanzhou , PR China.
² b The Provincial Education Key Laboratory of Screening, Evaluation and Advanced Processing of Traditional Chinese Medicine and Tibetan Medicine, School of Life Science and Engineering , Lanzhou University of Technology , Lanzhou , PR China.

PMID: 29421923
DOI: 10.1080/14786419.2018.1437437

Abstract

One new compound, colletotrichine B (1), was produced by the fungal Colletotrichum gloeosporioides GT-7. The structure of 1 was elucidated on the basis of spectroscopic analysis and X-ray crystallographic analysis. Monoamine oxidase (MAO), acetylcholinesterase (AChE) and phosphoinositide 3-kinase (PI3Kα) inhibitory activity of 1 was also evaluated. Compound 1 showed only AChE inhibiting activity with IC₅₀ value of 38.0 ± 2.67 μg/mL.

Keywords: PI3Kα inhibitor; acetylcholinesterase inhibitor; sesquiterpenoid.

MeSH terms

Cholinesterase Inhibitors / chemistry
Cholinesterase Inhibitors / isolation & purification*
Colletotrichum / chemistry*
Endophytes / chemistry*
Inhibitory Concentration 50
Molecular Structure
Monoamine Oxidase Inhibitors / chemistry
Monoamine Oxidase Inhibitors / isolation & purification
Phosphoinositide-3 Kinase Inhibitors
Sesquiterpenes / isolation & purification*
Uncaria / microbiology*

Substances

Cholinesterase Inhibitors
Monoamine Oxidase Inhibitors
Phosphoinositide-3 Kinase Inhibitors
Sesquiterpenes