Nanomedicines and gene therapy for the delivery of growth factors to improve perfusion and oxygenation in wound healing

Céline M Desmet; Véronique Préat; Bernard Gallez

doi:10.1016/j.addr.2018.02.001

Nanomedicines and gene therapy for the delivery of growth factors to improve perfusion and oxygenation in wound healing

Adv Drug Deliv Rev. 2018 Apr:129:262-284. doi: 10.1016/j.addr.2018.02.001. Epub 2018 Feb 12.

Authors

Céline M Desmet¹, Véronique Préat², Bernard Gallez¹

Affiliations

¹ Université catholique de Louvain, Louvain Drug Research Institute, Biomedical Magnetic Resonance Research Group, Brussels, Belgium.
² Université catholique de Louvain, Louvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, Brussels, Belgium. Electronic address: veronique.preat@uclouvain.be.

PMID: 29448035
DOI: 10.1016/j.addr.2018.02.001

Abstract

Oxygen plays a key role in wound healing, and hypoxia is a major cause of wound healing impairment; therefore, treatments to improve hemodynamics and increase wound oxygenation are of particular interest for the treatment of chronic wounds. This article describes the roles of oxygen and angiogenesis in wound healing as well as the tools used to evaluate tissue oxygenation and perfusion and then presents a review of nanomedicines and gene therapies designed to improve perfusion and oxygenation and accelerate wound healing.

Keywords: Diabetes; Gene therapy; Growth factors; Nanomedicines; Oxygenation; Perfusion; Skin; Wound healing.

Publication types

Review

MeSH terms

Gene Transfer Techniques*
Genetic Therapy*
Humans
Intercellular Signaling Peptides and Proteins / genetics*
Intercellular Signaling Peptides and Proteins / metabolism
Nanomedicine*
Oxygen / metabolism*
Perfusion*
Wound Healing / genetics*

Substances

Intercellular Signaling Peptides and Proteins
Oxygen