Magnetic Mesoporous Silica Nanoparticles Cloaked by Red Blood Cell Membranes: Applications in Cancer Therapy

Angew Chem Int Ed Engl. 2018 May 22;57(21):6049-6053. doi: 10.1002/anie.201712996. Epub 2018 Mar 24.

Abstract

Targeted drug delivery is an emerging technological strategy that enables nanoparticle systems to be responsive for tumor therapy. Magnetic mesoporous silica nanoparticles (MMSNs) were cloaked with red blood cell membrane (RBC). This integrates long circulation, photosensitizer delivery, and magnetic targeting for cancer therapy. In vivo experiments demonstrate that RBC@MMSNs can avoid immune clearance and achieve magnetic field (MF)-induced high accumulation in a tumor. When light irradiation is applied, singlet oxygen rapidly generates from hypocrellin B (HB)-loaded RBC@MMSN and leads to the necrosis of tumor tissue. Such a RBC-cloaked magnetic nanocarrier effectively integrates immunological adjuvant, photosensitizer delivery, MF-assisted targeting photodynamic therapy, which provides an innovative strategy for cancer therapy.

Keywords: magnetic nanoparticles; mesoporous silica; photodynamic therapy; red blood cell membrane; singlet oxygen.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cell Proliferation / drug effects
  • Drug Delivery Systems
  • Drug Screening Assays, Antitumor
  • Erythrocyte Membrane / chemistry*
  • HeLa Cells
  • Humans
  • Magnetite Nanoparticles / chemistry*
  • Neoplasms, Experimental / diagnostic imaging
  • Neoplasms, Experimental / drug therapy
  • Optical Imaging
  • Particle Size
  • Photochemotherapy*
  • Photosensitizing Agents / chemistry
  • Photosensitizing Agents / pharmacology*
  • Porosity
  • Silicon Dioxide / chemistry
  • Silicon Dioxide / pharmacology*
  • Surface Properties

Substances

  • Antineoplastic Agents
  • Magnetite Nanoparticles
  • Photosensitizing Agents
  • Silicon Dioxide