Triterpenoid saponins from Scabiosa stellata collected in North-eastern Algeria

Meryem Lehbili; Abdulmagid Alabdul Magid; Ahmed Kabouche; Laurence Voutquenne-Nazabadioko; Hamid Morjani; Dominique Harakat; Zahia Kabouche

doi:10.1016/j.phytochem.2018.03.005

Triterpenoid saponins from Scabiosa stellata collected in North-eastern Algeria

Phytochemistry. 2018 Jun:150:40-49. doi: 10.1016/j.phytochem.2018.03.005. Epub 2018 Mar 13.

Authors

Meryem Lehbili¹, Abdulmagid Alabdul Magid², Ahmed Kabouche³, Laurence Voutquenne-Nazabadioko⁴, Hamid Morjani⁵, Dominique Harakat⁶, Zahia Kabouche³

Affiliations

¹ Université des frères Mentouri-Constantine, Département de chimie, Laboratoire d'Obtention des Substances Thérapeutiques (LOST), Campus Chaabet-Ersas, 25000, Constantine, Algeria; ICMR-UMR CNRS 7312, Groupe Isolement et Structure, Campus Sciences, Bât. 18, BP 1039, 51687, Reims, France.
² ICMR-UMR CNRS 7312, Groupe Isolement et Structure, Campus Sciences, Bât. 18, BP 1039, 51687, Reims, France. Electronic address: abdulmagid.alabdulmagid@univ-reims.fr.
³ Université des frères Mentouri-Constantine, Département de chimie, Laboratoire d'Obtention des Substances Thérapeutiques (LOST), Campus Chaabet-Ersas, 25000, Constantine, Algeria.
⁴ ICMR-UMR CNRS 7312, Groupe Isolement et Structure, Campus Sciences, Bât. 18, BP 1039, 51687, Reims, France.
⁵ MEDyC UMR CNRS 7369, URCA, Faculté de Pharmacie, SFR CAP Santé, 1, rue du Maréchal-Juin, 51096, Reims, France.
⁶ Service Commun d'Analyses, Institut de Chimie Moléculaire de Reims (ICMR), CNRS UMR 7312, Bat. 18 B.P. 1039, 51687, Reims, Cedex 2, France.

PMID: 29547709
DOI: 10.1016/j.phytochem.2018.03.005

Abstract

Eight undescribed triterpenoid saponins, scabiostellatosides A-H, together with three known compounds were isolated from the whole plant of Scabiosa stellata L. Their structures were established by spectroscopic analyses (1D, 2D-NMR and HRESIMS) and chemical methods. Scabiostellatosides A-H were evaluated for their cytotoxicity against human fibrosarcoma cell line (HT1080). Scabiostellatoside F, a heptasaccharide derivative of oleanolic acid, exhibited moderate cytotoxicity against HT1080 cell line with IC₅₀ value of 12.0 μM.

Keywords: Caprifoliaceae; Cytotoxic activity; Scabiosa stellata L.; Triterpenoid saponins.

MeSH terms

Algeria
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
Cell Line, Tumor
Dipsacaceae / chemistry*
Drug Screening Assays, Antitumor
Humans
Inhibitory Concentration 50
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Oleanolic Acid / analogs & derivatives
Oleanolic Acid / chemistry
Oleanolic Acid / isolation & purification*
Oleanolic Acid / pharmacology
Saponins / chemistry
Saponins / isolation & purification*
Saponins / pharmacology
Triterpenes / chemistry
Triterpenes / isolation & purification*
Triterpenes / pharmacology

Substances

Antineoplastic Agents, Phytogenic
Saponins
Triterpenes
scabiostellatoside
Oleanolic Acid