SSTR-RADS Version 1.0 as a Reporting System for SSTR PET Imaging and Selection of Potential PRRT Candidates: A Proposed Standardization Framework

J Nucl Med. 2018 Jul;59(7):1085-1091. doi: 10.2967/jnumed.117.206631. Epub 2018 Mar 23.

Abstract

Reliable standards and criteria for somatostatin receptor (SSTR) PET are still lacking. We herein propose a structured reporting system on a 5-point scale for SSTR PET imaging, titled SSTR-RADS version 1.0, which might serve as a standardized assessment for both diagnosis and treatment planning in neuroendocrine tumors. SSTR-RADS could guide the imaging specialist in interpreting SSTR PET scans, facilitate communication with the referring clinician so that appropriate workup for equivocal findings is pursued, and serve as a reliable tool for patient selection for planned peptide receptor radionuclide therapy.

Keywords: 68Ga-DOTATATE/-TOC; PET; PRRT; RADS; SSTR; neuroendocrine tumor; peptide receptor radionuclide therapy; somatostatin receptor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Neoplasms / diagnostic imaging
  • Neoplasms / metabolism
  • Neoplasms / radiotherapy
  • Positron-Emission Tomography / standards*
  • Radiotherapy*
  • Receptors, Somatostatin / metabolism*
  • Reference Standards
  • Research Design*

Substances

  • Receptors, Somatostatin