Abstract
We have synthesized graphene oxide (GO) nanosheets using modified Hummer's method and conjugated it with doxorubicin (DOx), an anticancer drug. Drug release kinetics from GO-DOx conjugate indicated the drug release at acidic pH. MTT assay performed on FaDu hypopharyngeal cancer cell lines revealed that the GO-DOx nanoconjugate inhibited cell proliferation more efficiently compared with pure DOx. Preliminary results indicate the potential of designed GO-DOx drug conjugate for head and neck cancer.
Keywords:
doxorubicin; graphene oxide; head and neck cancer; nanomedicine.
MeSH terms
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Antibiotics, Antineoplastic / administration & dosage
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Antibiotics, Antineoplastic / pharmacology
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Carcinoma, Squamous Cell / drug therapy*
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Carcinoma, Squamous Cell / pathology
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Doxorubicin / administration & dosage*
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Doxorubicin / pharmacology
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Drug Liberation
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Graphite / administration & dosage
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Graphite / chemistry
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Graphite / pharmacology*
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Head and Neck Neoplasms / drug therapy
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Humans
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Hypopharyngeal Neoplasms / drug therapy*
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Hypopharyngeal Neoplasms / pathology
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Nanoconjugates / administration & dosage
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Nanoconjugates / chemistry
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Nanostructures / administration & dosage
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Nanostructures / chemistry*
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Oxides
Substances
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Antibiotics, Antineoplastic
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Nanoconjugates
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Oxides
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Graphite
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Doxorubicin