RETRACTED: GZMB gene silencing confers protection against synovial tissue hyperplasia and articular cartilage tissue injury in rheumatoid arthritis through the MAPK signaling pathway

Biomed Pharmacother. 2018 Jul:103:346-354. doi: 10.1016/j.biopha.2018.04.023. Epub 2018 Apr 24.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief. An Expression of Concern for this article was previously published while an investigation was conducted (see related editorial: https://doi.org/10.1016/j.biopha.2022.113812). This retraction notice supersedes the Expression of Concern published earlier. Concern was raised about the reliability of the Western blot data in Figure 7C, which appear to contain a similar phenotype to those found in other publications, as detailed here: https://pubpeer.com/publications/7DD2DDC979F8CE2B00555332B01F81; and here: https://docs.google.com/spreadsheets/d/1r0MyIYpagBc58BRF9c3luWNlCX8VUvUuPyYYXzxWvgY/edit#gid=262337249. The journal requested the corresponding author comment on these concerns and provide the associated raw data. The authors did not respond to this request and therefore the Editor-in-Chief decided to retract the article.

Keywords: Articular cartilage tissue injury; GZMB; MAPK signaling pathway; Rheumatoid arthritis; Synovial tissue hyperplasia.

Publication types

  • Retracted Publication

MeSH terms

  • Animals
  • Arthritis, Experimental / enzymology*
  • Arthritis, Experimental / genetics
  • Arthritis, Experimental / pathology
  • Cartilage, Articular / enzymology*
  • Cartilage, Articular / injuries
  • Gene Silencing / physiology
  • Granzymes / antagonists & inhibitors
  • Granzymes / genetics
  • Granzymes / metabolism*
  • Hyperplasia / enzymology*
  • Hyperplasia / genetics
  • Inflammation Mediators / antagonists & inhibitors
  • Inflammation Mediators / metabolism
  • MAP Kinase Signaling System / physiology*
  • Male
  • Rats
  • Rats, Wistar
  • Synovial Membrane / enzymology*
  • Synovial Membrane / pathology

Substances

  • Inflammation Mediators
  • Granzymes
  • Gzmb protein, rat