Clinical and Inflammatory Phenotyping: Can Electronic Nose and NMR-based Metabolomics Work at the Bedside?

Mauro Maniscalco; Andrea Motta

doi:10.1016/j.arcmed.2018.04.001

Clinical and Inflammatory Phenotyping: Can Electronic Nose and NMR-based Metabolomics Work at the Bedside?

Arch Med Res. 2018 Jan;49(1):74-76. doi: 10.1016/j.arcmed.2018.04.001. Epub 2018 Apr 17.

Authors

Mauro Maniscalco¹, Andrea Motta²

Affiliations

¹ Pulmonary Rehabilitation Division, ICS Maugeri SpA, IRCCS, Telese Terme (Benevento), Italy. Electronic address: mauromaniscalco@hotmail.com.
² Institute of Biomolecular Chemistry, National Research Council, Pozzuoli (Naples), Italy.

PMID: 29678351
DOI: 10.1016/j.arcmed.2018.04.001

Abstract

Electronic nose (eNose) and nuclear magnetic resonance (NMR)-based metabolomics seem to be able to identify metabolic and inflammatory profiles in patients with chronic obstructive diseases. The hypothesis arises from three recent studies using two different methods in patients with asthma and chronic obstructive pulmonary diseases (COPD), opening promising diagnostic perspectives. The possibility that the use of eNose and NMR-based metabolomics might provide clinical/inflammatory characteristics is intriguing. This might classify specific phenotypes of chronic airway disease regardless of the diagnosis asthma or COPD, therefore suggesting therapeutical targets for a personalized respiratory medicine through more efficient "tailored" strategies.

Keywords: Asthma; COPD; Inflammation; Metabolomics.

MeSH terms

Asthma / pathology*
Electronic Nose / statistics & numerical data*
Humans
Magnetic Resonance Imaging / methods*
Metabolomics
Phenotype
Pulmonary Disease, Chronic Obstructive / pathology*

Supplementary concepts

Pulmonary Disease, Chronic Obstructive, Severe Early-Onset