Targeting Regulatory T Cells to Treat Patients With Systemic Lupus Erythematosus

Front Immunol. 2018 Apr 17:9:786. doi: 10.3389/fimmu.2018.00786. eCollection 2018.

Abstract

Regulatory T cells (Tregs) are central in integration and maintenance of immune homeostasis. Since breakdown of self-tolerance is a major culprit in the pathogenesis of systemic lupus erythematosus (SLE), restoration of the immune tolerance through the manipulation of Tregs can be exploited to treat patients with SLE. New information has revealed that Tregs besides their role in suppressing the immune response are important in tissue protection and regeneration. Expansion of Tregs with low-dose IL-2 represents an approach to control the autoimmune response. Moreover, control of Treg metabolism can be exploited to restore or improve their function. Here, we summarize the function and diversity of Tregs and recent strategies to improve their function in patients with SLE.

Keywords: immunometabolism; low-dose IL-2 treatment; regulatory T cells; systemic lupus erythematosus; tissue Treg.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Immunotherapy / methods*
  • Interleukin-2 / immunology*
  • Lupus Erythematosus, Systemic / immunology*
  • Self Tolerance / immunology*
  • T-Lymphocytes, Regulatory / immunology*

Substances

  • Interleukin-2