Abstract
BODIPYs are photosensitizers activatable by light to generate highly reactive singlet oxygen (1O2) from molecular oxygen, leading to tissue damage in the photoirradiated region. Despite their extraordinary photophysical characteristics, they are not featured in clinical photodynamic therapy. This review discusses the recent advances in the design and/or modifications of BODIPYs since 2013, to improve their potential in photodynamic cancer therapy and related areas.
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / therapeutic use*
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Boron Compounds / chemical synthesis
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Boron Compounds / chemistry
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Boron Compounds / therapeutic use*
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Humans
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Neoplasms / drug therapy*
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Photochemotherapy*
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Photosensitizing Agents / chemical synthesis
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Photosensitizing Agents / chemistry
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Photosensitizing Agents / therapeutic use*
Substances
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4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
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Antineoplastic Agents
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Boron Compounds
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Photosensitizing Agents