Computer-aided design/computer-aided manufacturing (CAD-CAM) technology permits the angular correction of screw emergence into the prosthesis; however, there is lack of controlled clinical studies that assess the frequency of technical complications in angled screw channel restorations. This controlled clinical study was designed to assess technical incidences in angled screw channel restorations. Patients who underwent placement of implant prosthesis between November 2014 and December 2015 were screened. The patients were selected if they received a prosthesis with up to 30° correction of the prosthesis screw emergence and had at least 1 nonangulated prosthesis (screw retained). All prostheses were located completely/partially in the posterior region. The frequency of technical complications was the principal variable. A total of 52 patients with a mean age of 62 ± 10 years participated, with a total of 110 prostheses (55 in the test group and 55 in the control group). A total of 11 technical complications occurred (7 in the test group and 4 in the control group). These differences were not statistically significant. All prostheses in both groups survived the follow-up. The correction of the screw emergence into the prosthesis has not increased the risk of technical complications in CAD-CAM implant prostheses.