Abstract
Two different vasoactive intestinal peptide (VIP) amphiphiles have been formulated which readily form micelles of varying shapes. Interestingly, VIP micelle structure has been found to directly correlate to anti-inflammatory behavior providing evidence that these biomaterials can serve as a promising new therapeutic modality.
MeSH terms
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Animals
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Anti-Inflammatory Agents / pharmacology*
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B7-2 Antigen / genetics
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B7-2 Antigen / immunology
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Cells, Cultured
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Chemokine CCL22 / genetics
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Chemokine CCL22 / immunology
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Dendritic Cells / cytology
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Dendritic Cells / drug effects*
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Dendritic Cells / immunology
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Gene Expression
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Humans
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Immunologic Factors / pharmacology*
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Lipopolysaccharides / antagonists & inhibitors
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Lipopolysaccharides / pharmacology
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Macrophages / cytology
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Macrophages / drug effects*
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Macrophages / immunology
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Mice
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Micelles
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Protein Structure, Secondary
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Surface-Active Agents / chemistry
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T-Lymphocytes, Regulatory / cytology
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T-Lymphocytes, Regulatory / drug effects*
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T-Lymphocytes, Regulatory / immunology
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Tumor Necrosis Factor-alpha / antagonists & inhibitors
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Tumor Necrosis Factor-alpha / genetics
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Tumor Necrosis Factor-alpha / metabolism
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Vasoactive Intestinal Peptide / pharmacology*
Substances
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Anti-Inflammatory Agents
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B7-2 Antigen
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Ccl22 protein, mouse
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Cd86 protein, mouse
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Chemokine CCL22
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Immunologic Factors
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Lipopolysaccharides
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Micelles
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Surface-Active Agents
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Tumor Necrosis Factor-alpha
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Vasoactive Intestinal Peptide