Abstract
The granulocyte-macrophage colony-stimulating factors are well-characterized specific glycoproteins that interact to control the production, differentiation, and function of two related white cell populations of the blood, the granulocytes and monocyte-macrophages. Widely produced in the body, these regulators probably play an important role in resistance to infections. The proliferation of myeloid leukemia cells remains dependent on stimulation by colony-stimulating factors, although one of them also has the ability to suppress leukemic populations by inducing terminal differentiation.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Bone Marrow Cells
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Cell Differentiation
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Cell Division
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Cell Survival
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Cloning, Molecular
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Colony-Stimulating Factors / physiology*
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Granulocytes / physiology*
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Hematopoiesis*
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Humans
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Leukemia, Myeloid, Acute / physiopathology
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Macrophages / physiology*
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Mice
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Molecular Weight
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Receptors, Cell Surface / physiology
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Receptors, Colony-Stimulating Factor
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Species Specificity
Substances
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Colony-Stimulating Factors
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Receptors, Cell Surface
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Receptors, Colony-Stimulating Factor