Two-dimensional materials have been widely used as optical modulator materials in mode-locked fiber lasers. In terms of the performance of the fiber laser, one with an ultrashort pulse and high stability has great commercial value. Herein, the MoSe2 grown by the chemical vapor deposition (CVD) method with high modulation depth, quality lattice structure and uniformity is successfully applied in a mode-locked erbium-doped fiber laser. The pulse duration and signal-to-noise ratio of the laser are 207 fs and 85 dB, respectively. The multifarious performance comparisons indicate that the CVD-based MoSe2 saturable absorber with the tapered fiber structure has unique advantages not only in the generation of ultrashort pulses, but also in the optimization of laser stability.