Organelle Turnover: A USP30 Safety Catch Restrains the Trigger for Mitophagy and Pexophagy

Curr Biol. 2018 Aug 6;28(15):R842-R845. doi: 10.1016/j.cub.2018.06.067.

Abstract

It is crucial to remove dysfunctional mitochondria and peroxisomes to prevent cellular damage. Recent work suggests that under basal conditions USP30, a deubiquitinating enzyme, works to ensure that both of these organelles are only turned over at the right time.

Publication types

  • Comment

MeSH terms

  • Macroautophagy*
  • Mitochondrial Proteins
  • Mitophagy*
  • Peroxisomes
  • Thiolester Hydrolases

Substances

  • Mitochondrial Proteins
  • Thiolester Hydrolases