Pink1/Parkin link inflammation, mitochondrial stress, and neurodegeneration

J Cell Biol. 2018 Oct 1;217(10):3327-3329. doi: 10.1083/jcb.201808118. Epub 2018 Aug 28.

Abstract

What causes inflammation in age-related neurodegenerative diseases remains a mystery. Sliter et al. (2018. Nature https://doi.org/10.1038/s41586-018-0448-9) show that, when damaged mitochondria cannot be removed by mitophagy, stress from exercise or mitochondrial DNA mutations activates the proinflammatory cGAS-STING pathway that may contribute to Parkinson's disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Humans
  • Inflammation
  • Mitochondria
  • Mitophagy*
  • Protein Kinases*
  • Ubiquitin-Protein Ligases

Substances

  • Ubiquitin-Protein Ligases
  • Protein Kinases