Autophagy-independent effects of autophagy-related-5 (Atg5) on exosome production and metastasis

Huishan Guo; Remy Sadoul; Derrick Gibbings

doi:10.1080/23723556.2018.1445941

Autophagy-independent effects of autophagy-related-5 (Atg5) on exosome production and metastasis

Mol Cell Oncol. 2018 Apr 11;5(3):e1445941. doi: 10.1080/23723556.2018.1445941. eCollection 2018.

Authors

Huishan Guo^{1

2}, Remy Sadoul³, Derrick Gibbings^{1

2}

Affiliations

¹ Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada.
² Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Canada.
³ University Grenoble-Alpes, Grenoble Institute of Neuroscience, Grenoble 38706, France and Institut National de la Santé et de la Recherche Médicale (INSERM), Grenoble, France.

Abstract

Autophagy-related-5 (Atg5) and Autophagy-related-16-Like-1 (Atg16L1) canonically participate in autophagy. Recent research demonstrates that apart from this, they also control production of extracellular vesicles called exosomes by regulating acidification of late endosomes. Atg5-mediated exosome production increased migration and metastasis of breast cancer cells suggesting exosomes may perform some functions ascribed to autophagy.

Keywords: V1V0-ATPase; acidification; autophagy; biology of malignant cells; exosomes; mechanisms of oncogenesis and tumor progression; metastasis.

Grants and funding

National Sciences and Engineering Research Council of Canada (436104) Canadian Cancer Society Research Institute (CCSRI) (702978). R.S. was funded by Fondation France Alzheimer.