Abstract
The development and rapid spread of multidrug resistant (MDR) bacteria cause severe public crises. New antibacterial compounds are urgently needed to treat bacterial infections. By circumventing the disadvantages of cationic peptides here, we engineered a short, linear, low-cationic peptide bacaucin-1a, which exhibited remarkable antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). Bacaucin-1a was efficient in the prevention of MRSA associated infections in both in vitro and in vivo models with a unique mode of action. The discovery of low-cationic antibiotic candidates will extend our antibiotic pipeline in the fight against antibiotic resistant bacteria.
Keywords:
MRSA; antibacterial; antibiotic; peptides.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / therapeutic use*
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Antimicrobial Cationic Peptides / chemical synthesis*
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Antimicrobial Cationic Peptides / therapeutic use*
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Chlorocebus aethiops
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Disease Models, Animal
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Drug Resistance, Multiple, Bacterial
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Female
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Guanidine / chemistry
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Guanidine / pharmacology
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Methicillin-Resistant Staphylococcus aureus / drug effects*
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Mice
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Mice, Inbred BALB C
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Microbial Sensitivity Tests
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Peritonitis / microbiology
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Peritonitis / prevention & control
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Sepsis / microbiology
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Sepsis / prevention & control
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Staphylococcal Infections / microbiology
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Staphylococcal Infections / prevention & control*
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Structure-Activity Relationship
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Vero Cells
Substances
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Anti-Bacterial Agents
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Antimicrobial Cationic Peptides
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Guanidine