Emerging evidence linking the gut microbiome to neurologic disorders

Jessica A Griffiths; Sarkis K Mazmanian

doi:10.1186/s13073-018-0609-3

Emerging evidence linking the gut microbiome to neurologic disorders

Genome Med. 2018 Dec 21;10(1):98. doi: 10.1186/s13073-018-0609-3.

Authors

Jessica A Griffiths¹, Sarkis K Mazmanian²

Affiliations

¹ Division of Biology and Biological Engineering, California Institute of Technology, East California Boulevard, Pasadena, CA, 91125, USA. jgriffit@caltech.edu.
² Division of Biology and Biological Engineering, California Institute of Technology, East California Boulevard, Pasadena, CA, 91125, USA. sarkis@caltech.edu.

Abstract

The gut microbiome contributes to the development and function of the immune, metabolic, and nervous systems. Furthermore, commensal bacteria modulate symptoms and pathology in mouse models of neuropsychiatric and neurodevelopmental diseases. Uncovering mechanisms that are utilized by the microbiome to mediate gut-brain connections may provide novel opportunities to target therapies to the gut in order to treat neurologic disorders.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Bacteria*
Brain
Gastrointestinal Microbiome*
Genetic Predisposition to Disease
Humans
Mice
Nervous System Diseases / genetics
Nervous System Diseases / microbiology*
Polymorphism, Single Nucleotide

Grants and funding

R01 MH100556/MH/NIMH NIH HHS/United States