Abstract
We designed and synthesized a simple, but highly effective photosensitizer (G-Mito-Pc), which can precisely target the mitochondria of epidermal growth factor receptor (EGFR)-overexpressing cancer cells, to achieve dual targeting function at both cell and organelle levels in cancer therapy. We further explored the possible molecular mechanism of the enhanced bioactivity of G-Mito-Pc compared to that of the reference photosensitizer using molecular dynamics simulations on their interactions with a physiologically relevant mitochondrial membrane model.
MeSH terms
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Cell Survival / drug effects
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ErbB Receptors / genetics
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ErbB Receptors / metabolism
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HeLa Cells
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Humans
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Membrane Potential, Mitochondrial / drug effects
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Microscopy, Confocal
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Mitochondria / drug effects
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Mitochondria / metabolism*
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Molecular Dynamics Simulation
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Neoplasms / drug therapy
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Neoplasms / metabolism
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Neoplasms / pathology
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Photochemotherapy
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Photosensitizing Agents / chemistry*
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Photosensitizing Agents / metabolism
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Photosensitizing Agents / pharmacology
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Reactive Oxygen Species / metabolism
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Thermodynamics
Substances
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Photosensitizing Agents
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Reactive Oxygen Species
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ErbB Receptors