Double Infection With Leishmania tropica and L. major in an HIV Patient Controlled With High Doses of Amphotericin B

Asma Al Balushi; Faryal Khamis; Corné H W Klaassen; Jean-Pierre Gangneux; Jaap J Van Hellemond; Eskild Petersen

doi:10.1093/ofid/ofy323

Double Infection With Leishmania tropica and L. major in an HIV Patient Controlled With High Doses of Amphotericin B

Open Forum Infect Dis. 2018 Dec 7;5(12):ofy323. doi: 10.1093/ofid/ofy323. eCollection 2018 Dec.

Authors

Asma Al Balushi¹, Faryal Khamis¹, Corné H W Klaassen², Jean-Pierre Gangneux³, Jaap J Van Hellemond², Eskild Petersen¹

Affiliations

¹ Department of Infectious Diseases, The Royal Hospital, Muscat, Sultanate of Oman.
² Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
³ Centre Hospitalier Universitaire Pontchaillou, Rennes, France.

Abstract

We present a unique case of disseminated Leishmaniasis in an HIV patient. Two different Leishmania species were identified by genomic sequencing in both bone marrow and skin. The Leishmania infection could be suppressed but not cured, despite a high dose of amphotericin B of nearly 65 g over more than 6 years.

Keywords: CD4 cell count; HIV-coinfection; Leishmaniasis; amphotericin B; relapse.