Genetic engineering of hematopoiesis: current stage of clinical translation and future perspectives

EMBO Mol Med. 2019 Mar;11(3):e9958. doi: 10.15252/emmm.201809958.

Abstract

Here I review the scientific background, current stage of development and future perspectives that I foresee in the field of genetic manipulation of hematopoietic stem cells with a special emphasis on clinical applications.

Keywords: gene editing; gene therapy; hematopoietic stem cells; lentiviral vectors; transplantation.

Publication types

  • Review

MeSH terms

  • Animals
  • Genetic Engineering
  • Genetic Vectors / genetics
  • Hematopoiesis / genetics
  • Hematopoiesis / physiology*
  • Hematopoietic Stem Cells / metabolism*
  • Humans
  • Lentivirus / genetics