Why geneticists stole cancer research even though cancer is primarily a signaling disease

Michael B Yaffe

doi:10.1126/scisignal.aaw3483

Why geneticists stole cancer research even though cancer is primarily a signaling disease

Sci Signal. 2019 Jan 22;12(565):eaaw3483. doi: 10.1126/scisignal.aaw3483.

Author

Michael B Yaffe^{1

2}

Affiliations

¹ Chief Scientific Advisor and Academic Editor, Science Signaling, American Association for the Advancement of Science, Washington, DC 20005, USA. myaffe@mit.edu.
² David H. Koch Institute for Integrative Cancer Research, MIT Center for Precision Cancer Medicine, Broad Institute, and the Departments of Biology and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

PMID: 30670634
DOI: 10.1126/scisignal.aaw3483

Abstract

Genetic approaches to cancer research have dramatically advanced our understanding of the pathophysiology of this disease, leading to similar genetics-based approaches for precision therapy, which have been less successful. Reconfiguring and adapting the types of technologies that underlie genetic research to dissect tumor cell signaling in clinical samples may offer an alternative road forward.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Biomedical Research / methods
Biomedical Research / trends
Genetic Predisposition to Disease / genetics*
Genetics, Medical / methods*
Genome-Wide Association Study / methods*
Humans
Molecular Biology / methods*
Neoplasms / diagnosis
Neoplasms / genetics*
Neoplasms / therapy
Signal Transduction / genetics*