A selective chemiresistive sensor for the cancer-related volatile organic compound hexanal by using molecularly imprinted polymers and multiwalled carbon nanotubes

Mikrochim Acta. 2019 Feb 1;186(3):137. doi: 10.1007/s00604-019-3241-z.

Abstract

A chemiresistive sensor is described for the lung cancer biomarker hexanal. A composite consisting of molecularly imprinted polymer nanoparticles and multiwalled carbon nanotubes was used in the sensor that is typically operated at a voltage of 4 V and is capable of selectively sensing gaseous hexanal at room temperature. It works in the 10 to 200 ppm concentration range and has a 10 ppm detection limit (at S/N = 3). The sensor signal recovers to a value close to its starting value without the need for heating even after exposure to relatively high levels of hexanal. Graphical abstract Schematic presentation of a chemiresistive sensor for detection of hexanal, a cancer biomarker. The hexanal-imprinted polymeric nanoparticles were synthesized, mixed with multiwalled carbon nanotubes and coated on the surface of an interdigitated electrode to produce a nanocomposite chemiresistor gas sensor for hexanal.

Keywords: Chemiresistor; Gas sensor; Lung cancer; MWCNTs; Nanocomposite.

MeSH terms

  • Aldehydes / analysis*
  • Biomarkers, Tumor / analysis
  • Biosensing Techniques
  • Electrochemical Techniques
  • Electrodes
  • Gases / chemistry
  • Humans
  • Limit of Detection
  • Lung Neoplasms / diagnosis*
  • Methacrylates / chemistry
  • Molecular Imprinting*
  • Nanocomposites / chemistry
  • Nanoparticles / chemistry
  • Nanotubes, Carbon / chemistry*
  • Particle Size
  • Polymerization
  • Polymethyl Methacrylate / chemistry*
  • Surface Properties
  • Temperature
  • Volatile Organic Compounds / analysis*

Substances

  • Aldehydes
  • Biomarkers, Tumor
  • Gases
  • Methacrylates
  • Nanotubes, Carbon
  • Volatile Organic Compounds
  • methacrylic acid
  • Polymethyl Methacrylate
  • n-hexanal