Abstract
Three chloromethyl-modified Ru(ii) complexes were designed and synthesized as mitochondria targeting photosensitizers, which can generate carbon radicals in the presence of NADH under visible light irradiation, cause DNA cleavage and covalent binding in Ar-saturated solutions, and lead to apoptosis of human ovarian carcinoma SKOV-3 cells under hypoxic conditions (3% O2), demonstrating a new mode of type I mechanism to overcome the limitation of hypoxia in photodynamic therapy (PDT).
MeSH terms
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Apoptosis / drug effects
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Cell Hypoxia
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Cell Line, Tumor
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Coordination Complexes / chemistry*
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Coordination Complexes / pharmacology
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Coordination Complexes / therapeutic use
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DNA Cleavage / drug effects
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Humans
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Light
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Membrane Potential, Mitochondrial / drug effects
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Mitochondria / drug effects
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Mitochondria / metabolism*
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NAD / metabolism*
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Neoplasms / drug therapy
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Neoplasms / pathology
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Photochemotherapy
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Ruthenium / chemistry*
Substances
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Coordination Complexes
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NAD
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Ruthenium