Host tissue determinants of tumour immunity

Nat Rev Cancer. 2019 Apr;19(4):215-227. doi: 10.1038/s41568-019-0125-9.

Abstract

Although common evolutionary principles drive the growth of cancer cells regardless of the tissue of origin, the microenvironment in which tumours arise substantially differs across various organ sites. Recent studies have established that, in addition to cell-intrinsic effects, tumour growth regulation also depends on local cues driven by tissue environmental factors. In this Review, we discuss how tissue-specific determinants might influence tumour development and argue that unravelling the tissue-specific contribution to tumour immunity should help the development of precise immunotherapeutic strategies for patients with cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Proliferation / physiology
  • Humans
  • Neoplasms / immunology*
  • Neoplasms / pathology
  • Tumor Microenvironment / immunology