Luminescent Rhenium(I)-Polypyridine Complexes Appended with a Perylene Diimide or Benzoperylene Monoimide Moiety: Photophysics, Intracellular Sensing, and Photocytotoxic Activity

Chemistry. 2019 Jul 5;25(38):8970-8974. doi: 10.1002/chem.201900345. Epub 2019 Jun 5.

Abstract

This communication reports novel luminescent rhenium(I)-polypyridine complexes appended with a perylene diimide (PDI) or benzoperylene monoimide (BPMI) moiety through a non-conjugated linker. The photophysical and photochemical properties originating from the interactions of the metal polypyridine and perylene units were exploited to afford new cellular reagents with thiol-sensing capability and excellent photocytotoxic activity.

Keywords: fluorescence resonance energy transfer; perylene; phosphorogenic sensors; photocytotoxic agents; rhenium.

MeSH terms

  • Cell Survival / drug effects
  • Coordination Complexes / chemistry*
  • Coordination Complexes / toxicity
  • Fluorescence Resonance Energy Transfer
  • HeLa Cells
  • Humans
  • Luminescent Agents / chemistry*
  • Luminescent Agents / toxicity
  • Microscopy, Confocal
  • Optical Imaging
  • Perylene / analogs & derivatives*
  • Pyridines / chemistry*
  • Pyridines / toxicity
  • Rhenium / chemistry*
  • Rhenium / toxicity
  • Sulfhydryl Compounds / analysis

Substances

  • Coordination Complexes
  • Luminescent Agents
  • Pyridines
  • Sulfhydryl Compounds
  • Perylene
  • Rhenium