Beta Glucan: Supplement or Drug? From Laboratory to Clinical Trials

Molecules. 2019 Mar 30;24(7):1251. doi: 10.3390/molecules24071251.

Abstract

Glucans are part of a group of biologically active natural molecules and are steadily gaining strong attention not only as an important food supplement, but also as an immunostimulant and potential drug. This paper represents an up-to-date review of glucans (β-1,3-glucans) and their role in various immune reactions and the treatment of cancer. With more than 80 clinical trials evaluating their biological effects, the question is not if glucans will move from food supplement to widely accepted drug, but how soon.

Keywords: drug; food; glucan; immunity; infection; mushrooms; supplement.

Publication types

  • Review

MeSH terms

  • Adjuvants, Immunologic / chemistry*
  • Adjuvants, Immunologic / pharmacology
  • Agaricales / chemistry
  • Animals
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Dietary Supplements*
  • Gene Expression Regulation
  • Humans
  • Immune System / drug effects
  • Nutritive Value
  • Signal Transduction
  • beta-Glucans / chemistry*
  • beta-Glucans / pharmacology

Substances

  • Adjuvants, Immunologic
  • Antineoplastic Agents
  • beta-Glucans