Progress in the Chemistry of Tetrahydroquinolines

Isravel Muthukrishnan; Vellaisamy Sridharan; J Carlos Menéndez

doi:10.1021/acs.chemrev.8b00567

Progress in the Chemistry of Tetrahydroquinolines

Chem Rev. 2019 Apr 24;119(8):5057-5191. doi: 10.1021/acs.chemrev.8b00567. Epub 2019 Apr 9.

Authors

Isravel Muthukrishnan¹, Vellaisamy Sridharan^{1

2}, J Carlos Menéndez³

Affiliations

¹ Department of Chemistry, School of Chemical and Biotechnology , SASTRA Deemed University , Thanjavur 613401 , Tamil Nadu , India.
² Department of Chemistry and Chemical Sciences , Central University of Jammu , Rahya-Suchani (Bagla) , District-Samba, Jammu 181143 , Jammu and Kashmir , India.
³ Unidad de Química Orgańica y Farmacéutica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia , Universidad Complutense , 28040 Madrid , Spain.

PMID: 30963764
DOI: 10.1021/acs.chemrev.8b00567

Abstract

Tetrahydroquinoline is one of the most important simple nitrogen heterocycles, being widespread in nature and present in a broad variety of pharmacologically active compounds. This Review summarizes the progress achieved in the chemistry of tetrahydroquinolines, with emphasis on their synthesis, during the period from mid-2010 to early 2018.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Anti-HIV Agents / chemistry
Anti-HIV Agents / pharmacology
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology
Humans
Molecular Targeted Therapy
Quinolines / chemistry*
Quinolines / pharmacology*

Substances

Anti-HIV Agents
Antineoplastic Agents
Quinolines
1,2,3,4-tetrahydroquinoline