Primary graft dysfunction after heart transplantation: a thorn amongst the roses

Heart Fail Rev. 2019 Sep;24(5):805-820. doi: 10.1007/s10741-019-09794-1.

Abstract

Primary graft dysfunction (PGD) remains the leading cause of early mortality post-heart transplantation. Despite improvements in mechanical circulatory support and critical care measures, the rate of PGD remains significant. A recent consensus statement by the International Society of Heart and Lung Transplantation (ISHLT) has formulated a definition for PGD. Five years on, we look at current concepts and future directions of PGD in the current era of transplantation.

Keywords: Management; Pathophysiology; Prevention; Primary graft dysfunction; Treatment.

Publication types

  • Review

MeSH terms

  • Biomarkers
  • Catecholamines / therapeutic use
  • Female
  • Graft Rejection / prevention & control
  • Heart Transplantation / adverse effects*
  • Humans
  • Incidence
  • Male
  • Phosphodiesterase Inhibitors / therapeutic use
  • Plasmapheresis
  • Primary Graft Dysfunction / epidemiology*
  • Primary Graft Dysfunction / physiopathology
  • Primary Graft Dysfunction / prevention & control*
  • Risk Factors
  • Terminology as Topic
  • Tissue Donors
  • Transplant Recipients

Substances

  • Biomarkers
  • Catecholamines
  • Phosphodiesterase Inhibitors