Single-Atom Nanozyme Based on Nanoengineered Fe-N-C Catalyst with Superior Peroxidase-Like Activity for Ultrasensitive Bioassays

Nan Cheng; Jin-Cheng Li; Dong Liu; Yuehe Lin; Dan Du

doi:10.1002/smll.201901485

Single-Atom Nanozyme Based on Nanoengineered Fe-N-C Catalyst with Superior Peroxidase-Like Activity for Ultrasensitive Bioassays

Small. 2019 Nov;15(48):e1901485. doi: 10.1002/smll.201901485. Epub 2019 May 21.

Authors

Nan Cheng¹, Jin-Cheng Li¹, Dong Liu¹, Yuehe Lin¹, Dan Du¹

Affiliation

¹ School of Mechanical and Materials Engineering, Washington State University, Pullman, WA, 99164, USA.

PMID: 31111647
DOI: 10.1002/smll.201901485

Abstract

Single-atom catalysts are becoming a hot research topic owing to their unique characteristics of maximum specific activity and atomic utilization. Herein, a new single-atom nanozyme (SAN) based on single Fe atoms anchored on N-doped carbons supported on carbon nanotube (CNT/FeNC) is proposed. The CNT/FeNC with robust atomic Fe-N_x moieties is synthesised, showing superior peroxidase-like activity. Furthermore, the CNT/FeNC is used as the signal element in a series of paper-based bioassays for ultrasensitive detection of H₂ O₂ , glucose, and ascorbic acid. The SAN provides a new type of signal element for developing various biosensing techniques.

Keywords: Fe-N-C catalysis; paper bioassays; peroxidase-like activity; single-atom nanozyme.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Biological Assay*
Catalysis
Nanoparticles / chemistry*
Nanoparticles / ultrastructure
Nanotechnology*
Nanotubes, Carbon / ultrastructure
Peroxidase / metabolism*
Time Factors

Substances

Nanotubes, Carbon
Peroxidase