Luminescent Ru(ii)-thiol modified silver nanoparticles for lysosome targeted theranostics

Maierhaba Wumaier; Tian-Ming Yao; Xiao-Chun Hu; Zhi-An Hu; Shuo Shi

doi:10.1039/c9dt00878k

Luminescent Ru(ii)-thiol modified silver nanoparticles for lysosome targeted theranostics

Dalton Trans. 2019 Jul 16;48(28):10393-10397. doi: 10.1039/c9dt00878k.

Authors

Maierhaba Wumaier¹, Tian-Ming Yao¹, Xiao-Chun Hu¹, Zhi-An Hu¹, Shuo Shi²

Affiliations

¹ Shanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Tongji University, Shanghai 200092, PR China. shishuo@tongji.edu.cn tmyao@tongji.edu.cn.
² Shanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Tongji University, Shanghai 200092, PR China. shishuo@tongji.edu.cn tmyao@tongji.edu.cn and Biomedical Multidisciplinary Innovation Research Institute, Shanghai East Hospital, Tongji University, Shanghai 200092, PR China.

PMID: 31162516
DOI: 10.1039/c9dt00878k

Abstract

Silver nanoparticles (AgNPs) modified by luminescent Ru(ii) complexes not only possess bright red fluorescence but also can target lysosomes. Cell imaging and a cytotoxicity study suggest that Ru1-2·AgNPs may act as a potential theranostic agent.

MeSH terms

Cell Survival / drug effects
HeLa Cells
Humans
Luminescence*
Lysosomes / drug effects
Metal Nanoparticles / chemistry*
Optical Imaging
Particle Size
Ruthenium / chemistry
Ruthenium / pharmacology*
Silver / chemistry
Silver / pharmacology*
Sulfhydryl Compounds / chemistry
Sulfhydryl Compounds / pharmacology*
Surface Properties
Theranostic Nanomedicine*

Substances

Sulfhydryl Compounds
Silver
Ruthenium