Abstract
The causal link between iron and atherosclerosis has been debated. Recent studies have revisited the 'iron hypothesis' by showing that dietary iron overload or elevated non-transferrin bound iron (NTBI) aggravates atherosclerosis in mice by driving vascular dysfunction, thus identifying NTBI as a risk factor and therapeutic target for atherosclerosis.
Keywords:
atherosclerosis; inflammation; iron hypothesis; metabolism.
Copyright © 2019 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Atherosclerosis / etiology*
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Atherosclerosis / metabolism*
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Biomarkers
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Blood Platelets / metabolism
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Disease Models, Animal
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Disease Susceptibility*
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Endothelial Cells / metabolism
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Endothelial Cells / pathology
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Endothelium / metabolism
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Endothelium / pathology
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Genetic Predisposition to Disease
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Humans
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Iron / metabolism*
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Macrophages / immunology
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Macrophages / metabolism
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Myocytes, Smooth Muscle / metabolism