Abstract
Phosphatidylcholine is the main component of liposomes and other phospholipid-based nanocarriers in drug delivery. However, the functions and applications of these nanocarriers are extremely limited by conventional phospholipids. Here we report novel disulfide phosphatidylcholines (SS-PCs) and SS-PC based liposomes (SS-LPs) used as alternatives to traditional phospholipids and liposomes.
MeSH terms
-
Animals
-
Antineoplastic Agents / chemistry
-
Antineoplastic Agents / pharmacology
-
Antineoplastic Agents / therapeutic use
-
Cell Line, Tumor
-
Disulfides / chemical synthesis
-
Disulfides / chemistry*
-
Disulfides / metabolism
-
Doxorubicin / chemistry
-
Doxorubicin / pharmacology
-
Doxorubicin / therapeutic use
-
Drug Carriers / chemical synthesis
-
Drug Carriers / chemistry*
-
Drug Carriers / metabolism
-
Humans
-
Liposomes / chemical synthesis
-
Liposomes / chemistry*
-
Liposomes / metabolism
-
Mice
-
Oxidation-Reduction
-
Phosphatidylcholines / chemical synthesis
-
Phosphatidylcholines / chemistry*
-
Phosphatidylcholines / metabolism
Substances
-
Antineoplastic Agents
-
Disulfides
-
Drug Carriers
-
Liposomes
-
Phosphatidylcholines
-
Doxorubicin