Review: The role of computational simulation in understanding the postoperative sinonasal environment

Clin Biomech (Bristol, Avon). 2019 Aug:68:212-220. doi: 10.1016/j.clinbiomech.2018.01.011. Epub 2018 Jan 31.

Abstract

Nasal surgery improves symptoms in a majority of patients for whom medical treatment has failed. In rhinosinusitis patients, endoscopic sinus surgery aims to alleviate obstruction and re-establish mucociliary clearance. Surgery alters the structure-function relationship within the nasal passage, which is difficult to assess clinically. Computational modelling has been used to investigate this relationship by simulating air flow and environmental variables inside realistic three-dimensional models of the human nasal airway but many questions remain unanswered and need further investigation. The application of computational models to improve pre-surgical planning and post-surgical treatment may not be currently possible due to the absence of knowledge correlating the model-predicted parameters to physiological variables. Links between these parameters to patient outcomes are yet to be established. This article reviews the recent application of computational modelling to understand the nasal structure-function relationship following surgery in patients with sinusitis and nasal obstruction.

Keywords: Computational fluid dynamics; Endoscopic surgery; Patient outcomes; Rhinosinusitis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Chronic Disease
  • Computer Simulation*
  • Drug Delivery Systems
  • Endoscopy
  • Humans
  • Hydrodynamics
  • Imaging, Three-Dimensional
  • Magnetic Resonance Imaging
  • Models, Biological
  • Nasal Sprays
  • Nebulizers and Vaporizers
  • Paranasal Sinuses / anatomy & histology*
  • Paranasal Sinuses / diagnostic imaging*
  • Paranasal Sinuses / surgery*
  • Postoperative Period
  • Sinusitis / diagnostic imaging*
  • Tomography, X-Ray Computed
  • Treatment Outcome

Substances

  • Nasal Sprays