Global Investigations of Fusobacterium nucleatum in Human Colorectal Cancer

Seul A Lee; Fang Liu; Stephen M Riordan; Cheok S Lee; Li Zhang

doi:10.3389/fonc.2019.00566

Global Investigations of Fusobacterium nucleatum in Human Colorectal Cancer

Front Oncol. 2019 Jul 3:9:566. doi: 10.3389/fonc.2019.00566. eCollection 2019.

Authors

Seul A Lee¹, Fang Liu¹, Stephen M Riordan², Cheok S Lee^{3

4

5

6}, Li Zhang¹

Affiliations

¹ School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia.
² Gastrointestinal and Liver Unit, Prince of Wales Hospital, University of New South Wales, Sydney, NSW, Australia.
³ Discipline of Pathology, School of Medicine, Western Sydney University, Sydney, NSW, Australia.
⁴ Faculty of Medicine and Health, Central Clinical School, University of Sydney, Sydney, NSW, Australia.
⁵ Faculty of Medicine, South Western Sydney Clinical School, University of New South Wales, Sydney, NSW, Australia.
⁶ Department of Anatomical Pathology, Liverpool Hospital, Sydney, NSW, Australia.

Abstract

Colorectal cancer (CRC) is the third most prevalent cancer and second in terms of mortality. Emerging evidence from recent studies suggests a potential role of Fusobacterium nucleatum in the development of CRC. In this article, we review studies from different geographical regions examining the association between F. nucleatum and CRC, the detection methods and the tumorigenic mechanisms. Furthermore, we discuss the potential clinical impact of F. nucleatum in CRC and suggest future study directions.

Keywords: CRC; F. nucleatum; Fusobacterium nucleatum; colorectal cancer; tumorigenic mechanisms.

Publication types

Review