Abstract
Lung cancer remains one of the most genetically complex, aggressive, and lethal solid malignancies. Understanding how distinct lung cancer mutations give rise to altered nutrient requirements and promote immune evasion in the context of a heterogeneous lung tumor microenvironment is vital for the development of novel personalized therapeutic strategies.
Keywords:
KEAP1; STK11/LKB1; immune evasion; lung cancer; metabolism; microenvironment.
Copyright © 2019 Elsevier Inc. All rights reserved.
MeSH terms
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Adenocarcinoma of Lung / drug therapy*
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Adenocarcinoma of Lung / genetics
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Adenocarcinoma of Lung / immunology
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Adenocarcinoma of Lung / metabolism
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Antineoplastic Agents, Immunological / pharmacology
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Antineoplastic Agents, Immunological / therapeutic use*
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Biomarkers, Tumor / antagonists & inhibitors*
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Biomarkers, Tumor / genetics
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Biosynthetic Pathways / drug effects
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Biosynthetic Pathways / genetics
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Genes, Tumor Suppressor
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Humans
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Lung Neoplasms / drug therapy*
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Lung Neoplasms / genetics
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Lung Neoplasms / immunology
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Lung Neoplasms / metabolism
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Mutation
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Oncogenes / genetics
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Precision Medicine / methods
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Precision Medicine / trends
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Tumor Escape / drug effects
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Tumor Escape / genetics
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Tumor Microenvironment / drug effects
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Tumor Microenvironment / genetics
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Tumor Microenvironment / immunology
Substances
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Antineoplastic Agents, Immunological
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Biomarkers, Tumor