Comorbid and inflammatory characteristics of genetic subtypes of clonal hematopoiesis

Blood Adv. 2019 Aug 27;3(16):2482-2486. doi: 10.1182/bloodadvances.2018024729.

Abstract

  1. CH may be associated with broader ill health (worse performance status, increased and potentially novel comorbidities).

  2. Serum interleukin-6 is elevated in people with CH and genetic subtypes, providing a view of the human systemic inflammatory landscape of CH.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers
  • Clonal Evolution / genetics*
  • Comorbidity
  • Computational Biology / methods
  • Cross-Sectional Studies
  • Cytokines / metabolism
  • Gene Expression Profiling
  • Genetic Predisposition to Disease*
  • Hematopoiesis / genetics*
  • Humans
  • Mutation
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Odds Ratio

Substances

  • Biomarkers
  • Cytokines