Disseminated Emergomycosis in a Person with HIV Infection, Uganda

Emerg Infect Dis. 2019 Sep;25(9):1750-1751. doi: 10.3201/eid2509.181234.

Abstract

We describe emergomycosis in a patient in Uganda with HIV infection. We tested a formalin-fixed, paraffin-embedded skin biopsy to identify Emergomyces pasteurianus or a closely related pathogen by sequencing broad-range fungal PCR amplicons. Results suggest that emergomycosis is more widespread and genetically diverse than previously documented. PCR on tissue blocks may help clarify emergomycosis epidemiology.

Keywords: Broad-range fungal PCR; Emergomycosis; FFPE; Formalin-fixed paraffin-embedded biopsy; Fungi; HIV/AIDS and other retroviruses; Uganda.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antifungal Agents / therapeutic use
  • Chrysosporium / genetics
  • Chrysosporium / isolation & purification*
  • Diagnosis, Differential
  • Female
  • HIV Infections*
  • Humans
  • Itraconazole / therapeutic use
  • Mycoses / diagnosis*
  • Mycoses / drug therapy
  • Mycoses / microbiology
  • Polymerase Chain Reaction
  • Uganda

Substances

  • Antifungal Agents
  • Itraconazole