Background: Adiponectin gene polymorphisms have recently been reported to be associated with obesity. In Egypt, obesity has expanded especially with the changing nourishment propensities and the inexorably inactive ways of life, with almost 70 percent of the Egyptian populations being obese.
Aim: To assess the relationship of the adiponectin gene (ADIPOQ) polymorphism in patients with Obesity in Egyptians.
Subjects and methods: This study included 100 patients with obesity and 97 random controls.
Results: Adiponectin rs1501299 polymorphism showed significant difference cases with different obesity grades where the T/T genotype was relatively higher in higher classes of obesity (Class II and III; (66.7% and 55.6% respectively, p = 000), which determines the susceptibility to obesity.
Conclusion: Adiponectin rs1501299 polymorphism might be a candidate gene, which determines the susceptibility to obesity. Larger studies are necessary to confirm these findings in various populations.
Keywords: Egypt; Obesity; adiponectin; polymorphism.