Compartmentalized DNA repair: Rif1 S-acylation links DNA double-strand break repair to the nuclear membrane

Gabriele A Fontana; Ulrich Rass

doi:10.1080/23723556.2019.1648025

Compartmentalized DNA repair: Rif1 S-acylation links DNA double-strand break repair to the nuclear membrane

Mol Cell Oncol. 2019 Aug 21;6(6):e1648025. doi: 10.1080/23723556.2019.1648025. eCollection 2019.

Authors

Gabriele A Fontana¹, Ulrich Rass²

Affiliations

¹ Department of Health Sciences and Technology, ETH Zürich, Zurich, Switzerland.
² Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK.

Abstract

DNA double-strand breaks (DSBs) disrupt the structural integrity of chromosomes. Proper DSB repair pathway choice is critical to avoid the type of gross chromosomal rearrangements that characterize cancer cells. Recent findings reveal S-fatty acylation and membrane anchorage of Rap1-interacting factor 1 (Rif1) as a mechanism providing spatial control over DSB repair pathway choice.

Keywords: DHHC palmitoyl transferases; HR; NHEJ; Pfa4; chromosome stability; protein palmitoylation.

Grants and funding

For the work described here, the authors have received support by the Novartis Research Foundation.