Green tea polyphenols and epigallocatechin-3-gallate protect against perfluorodecanoic acid induced liver damage and inflammation in mice by inhibiting NLRP3 inflammasome activation

Dongxu Wang; Qiang Gao; Taotao Wang; Zhipeng Kan; Xin Li; Lizhen Hu; Chuan-Yi Peng; Frank Qian; Yijun Wang; Daniel Granato

doi:10.1016/j.foodres.2019.108628

Green tea polyphenols and epigallocatechin-3-gallate protect against perfluorodecanoic acid induced liver damage and inflammation in mice by inhibiting NLRP3 inflammasome activation

Food Res Int. 2020 Jan:127:108628. doi: 10.1016/j.foodres.2019.108628. Epub 2019 Aug 19.

Authors

Dongxu Wang¹, Qiang Gao¹, Taotao Wang², Zhipeng Kan¹, Xin Li¹, Lizhen Hu¹, Chuan-Yi Peng¹, Frank Qian³, Yijun Wang⁴, Daniel Granato⁵

Affiliations

¹ State Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Science & Technology, Anhui Agricultural University, Hefei, Anhui 230036, PR China.
² Department of Clinical Nutrition, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212000, PR China.
³ Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA.
⁴ State Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Science & Technology, Anhui Agricultural University, Hefei, Anhui 230036, PR China. Electronic address: yijun@ahau.edu.cn.
⁵ Food Processing and Quality, Production Systems Unit, Natural Resources Institute Finland, Luke, Maarintie 6, Open Innovation House, FI-02150 Espoo, Finland. Electronic address: daniel.granato@luke.fi.

PMID: 31882076
DOI: 10.1016/j.foodres.2019.108628

Abstract

Perfluorodecanoic acid (PFDA) is a highly toxic food contaminant that is extensively used in food applications as surface antifouling agent. In this present study, we aimed to assess whether green tea polyphenols (GTPs) and epigallocatechin-3-gallate (EGCG) exert protective effects against PFDA-induced liver damage and inflammation in mice. A mouse model to evaluate liver toxicity was established by giving mice drinking water containing different concentrations of PFDA. GTPs or EGCG (0.32%, w/v) were co-administered to mice exposed to PFDA in drinking water. Overall, GTPs and EGCG extended the survival time and inhibited weight loss among mice who received a lower dose of PFDA. Moreover, GTPs and EGCG ameliorated hepatic oxidative stress, cell apoptosis, necrosis, steatosis, edema, and degeneration, reduced hepatic inflammation and NLRP3 inflammasome activation caused by a moderate dose of PFDA. Taken together, these results show that GTPs or EGCG (or green tea intake) supplements can be beneficial for people exposed to PFDA.

Keywords: EGCG; Functional foods; Green tea polyphenols; In vivo study; NLRP3 inflammasome; Oxidative stress; Perfluorodecanoic acid; Tea catechins.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antioxidants / pharmacology
Catechin / analogs & derivatives*
Catechin / pharmacology
Decanoic Acids
Disease Models, Animal
Fluorocarbons
Inflammasomes / drug effects*
Inflammation / prevention & control*
Liver Diseases / prevention & control*
Male
Mice
NLR Family, Pyrin Domain-Containing 3 Protein / drug effects*
Polyphenols / pharmacology*
Tea*

Substances

Antioxidants
Decanoic Acids
Fluorocarbons
Inflammasomes
NLR Family, Pyrin Domain-Containing 3 Protein
Nlrp3 protein, mouse
Polyphenols
Tea
perfluorodecanoic acid
Catechin
epigallocatechin gallate