Reinforcement of Polycaprolactone/Chitosan with Nanoclay and Controlled Release of Curcumin for Wound Dressing

Yanping Huang; Nianhua Dan; Weihua Dan; Weifeng Zhao

doi:10.1021/acsomega.9b02217

Reinforcement of Polycaprolactone/Chitosan with Nanoclay and Controlled Release of Curcumin for Wound Dressing

ACS Omega. 2019 Dec 19;4(27):22292-22301. doi: 10.1021/acsomega.9b02217. eCollection 2019 Dec 31.

Authors

Yanping Huang¹, Nianhua Dan¹, Weihua Dan¹, Weifeng Zhao¹

Affiliation

¹ College of Biomass Science and Engineering, Key Laboratory for Leather Chemistry and Engineering of the Education Ministry, Research Center of Biomedical Engineering, and College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.

Abstract

A novel clay-reinforced polycaprolactone/chitosan/curcumin (PCl/CS/Clay/Cur) composite film was fabricated in this study. The prepared Cur-loading composite films were characterized with attenuated total reflection Fourier transformed infrared spectroscopy, scanning electron microscopy, atomic force microscopy, water contact angle, differential scanning calorimetry, thermogravimetric analysis, and X-ray diffraction, and the results showed good dispersion of clay in the composite films. The addition of nanoclay was found to significantly increase the tensile strength. Also, the clay-enhanced drug-loading films exhibited better controlled-release profiles of Cur than those membranes without clay. Skin disinfection test demonstrated that the curcumin-loaded film could protect wound from bacterial infection. Cytotoxicity analysis proved the good biocompatibility of the composite films. The clay-enhanced Cur-loading films might be promising candidates for wound care.