Ruxolitinib can cause weight gain by blocking leptin signaling in the brain via JAK2/STAT3

Blood. 2020 Mar 26;135(13):1062-1066. doi: 10.1182/blood.2019003050.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain / metabolism*
  • Humans
  • Janus Kinase 2 / metabolism*
  • Leptin / metabolism*
  • Nitriles
  • Protein Kinase Inhibitors / adverse effects*
  • Pyrazoles / adverse effects*
  • Pyrimidines
  • STAT3 Transcription Factor / metabolism*
  • Signal Transduction / drug effects*
  • Weight Gain / drug effects

Substances

  • Leptin
  • Nitriles
  • Protein Kinase Inhibitors
  • Pyrazoles
  • Pyrimidines
  • STAT3 Transcription Factor
  • STAT3 protein, human
  • ruxolitinib
  • JAK2 protein, human
  • Janus Kinase 2