RNA-based pharmacotherapy for tumors: From bench to clinic and back

Xiangping Liang; Dongpei Li; Shuilong Leng; Xiao Zhu

doi:10.1016/j.biopha.2020.109997

RNA-based pharmacotherapy for tumors: From bench to clinic and back

Biomed Pharmacother. 2020 May:125:109997. doi: 10.1016/j.biopha.2020.109997. Epub 2020 Feb 13.

Authors

Xiangping Liang¹, Dongpei Li², Shuilong Leng³, Xiao Zhu⁴

Affiliations

¹ Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical University, Zhanjiang, China; Southern Marine Science and Engineering Guangdong Laboratory Zhanjiang, The Marine Medical Research Institute of Guangdong Zhanjiang (GDZJMMRI), Guangdong Medical University, Zhanjiang, China.
² Southern Marine Science and Engineering Guangdong Laboratory Zhanjiang, The Marine Medical Research Institute of Guangdong Zhanjiang (GDZJMMRI), Guangdong Medical University, Zhanjiang, China.
³ Key Laboratory of Neurological Function and Health, School of Basic Medical Sciences, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, China. Electronic address: shuilongleng@gzhmu.edu.cn.
⁴ Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical University, Zhanjiang, China; Southern Marine Science and Engineering Guangdong Laboratory Zhanjiang, The Marine Medical Research Institute of Guangdong Zhanjiang (GDZJMMRI), Guangdong Medical University, Zhanjiang, China. Electronic address: xzhu@gdmu.edu.cn.

PMID: 32062550
DOI: 10.1016/j.biopha.2020.109997

Abstract

RNA therapy is a treatment that regulates cell proteins and cures diseases by affecting the metabolism of mRNAs in cells, which has cut a figure in the studies on various incurable illnesses like hereditary diseases, tumors, etc. In this review, we introduced the discovery and development of RNA therapy and discussed its classification, mechanisms, advantages, and challenges. Moreover, we highlighted how RNA therapy works in killing tumor cells as well as what progresses it has made in related researches. And the development of RNA anti-tumor drugs and the clinical trial process were also included.

Keywords: Cancer immunotherapy; Clinical trials; RNA drugs; RNA therapy.

Publication types

Review

MeSH terms

Animals
Biomarkers, Tumor / genetics*
Cellular Reprogramming
Genetic Therapy* / adverse effects
Genetic Therapy* / methods
Humans
Immunotherapy
Molecular Targeted Therapy
Neoplasm Grading
Neoplasm Staging
Neoplasms / genetics*
Neoplasms / pathology
Neoplasms / therapy*
RNA Interference
RNA*
RNA, Antisense / genetics
RNA, Antisense / therapeutic use
RNA, Messenger / genetics
RNA, Messenger / therapeutic use
Translational Research, Biomedical

Substances

Biomarkers, Tumor
RNA, Antisense
RNA, Messenger
RNA