Streptococcus agalactiae infections and clinical relevance in adults, Thailand

Diagn Microbiol Infect Dis. 2020 May;97(1):115005. doi: 10.1016/j.diagmicrobio.2020.115005. Epub 2020 Jan 30.

Abstract

Streptococcus agalactiae is an important pathogen that causes infections in neonates and adults; infections especially in nonpregnant adults are increasing worldwide. Of 1736 S. agalactiae isolates from individuals throughout Thailand, serotypes III (46.4%) and V (21%) were demonstrated to be the most common serotypes. Human cases (56.5% female and 43.5% male) could be found all year round, with the peak occurring more frequently during the rainy season (May-October). The mortality rate of S. agalactiae infections was 11.6%, and serotype III was the most common serotype involved. Serotype III was strongly significantly (P value <0.001) correlated with meningitis (odds ratio [OR] = 26.72), sepsis (OR = 5.56), and septic arthritis (OR = 22.79). Serotype V was more associated with urinary tract infection than other serotypes. (P value = 0.005; OR = 2.32).

Keywords: Group B streptococcus; Sepsis; Serotype; Streptococcus agalactiae; Urinary tract infection (UTI).

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Arthritis, Infectious / epidemiology
  • Arthritis, Infectious / microbiology
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Male
  • Meningitis / epidemiology
  • Meningitis / microbiology
  • Middle Aged
  • Prospective Studies
  • Seasons
  • Sepsis / epidemiology
  • Sepsis / microbiology
  • Serogroup*
  • Streptococcal Infections / complications*
  • Streptococcal Infections / epidemiology*
  • Streptococcal Infections / mortality
  • Streptococcus agalactiae
  • Tertiary Care Centers / statistics & numerical data
  • Thailand / epidemiology
  • Urinary Tract Infections / epidemiology
  • Urinary Tract Infections / microbiology
  • Young Adult