Liquid-Phase Exfoliation and Functionalization of MoS2 Nanosheets for Effective Antibacterial Application

Chembiochem. 2020 Aug 17;21(16):2373-2380. doi: 10.1002/cbic.202000195. Epub 2020 Apr 30.

Abstract

A lysozyme (Lys)-assisted liquid-phase exfoliation technique was designed to synthesize MoS2 nanosheets (MoS2 -Lys NSs). As a novel nanozyme antibacterial agent with high peroxidase-like catalyst activity, MoS2 -Lys NSs showed good antibacterial efficacy against both Gram-negative ampicillin-resistant Escherichia coli (Ampr E. coli) and Gram-positive Bacillus subtilis. A possible antibacterial mechanism is also proposed. This work provides an effective antibacterial strategy based on the MoS2 -Lys NSs antibacterial agent.

Keywords: MoS2-Lys NSs; antibacterial activity; catalysts; peroxidases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology*
  • Bacillus subtilis / drug effects
  • Catalysis
  • Disulfides / chemistry*
  • Disulfides / pharmacology*
  • Escherichia coli / drug effects
  • Molybdenum / chemistry*
  • Molybdenum / pharmacology*
  • Nanostructures / chemistry*

Substances

  • Anti-Bacterial Agents
  • Disulfides
  • Molybdenum
  • molybdenum disulfide